Daniel Freilich Selected Research

Hemorrhagic Shock

2/2013	Fluid resuscitation of uncontrolled hemorrhage using a hemoglobin-based oxygen carrier: effect of traumatic brain injury.
2/2012	Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine.
6/2011	Amylase and lipase detection in hemorrhaged animals treated with HBOC-201.
4/2010	Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation.
2/2009	HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials.
6/2008	Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model.
5/2008	The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock.
11/2007	Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.
8/2007	Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care.
11/2006	Vasoactivity of bovine polymerized hemoglobin (HBOC-201) in swine with traumatic hemorrhagic shock with and without brain injury.

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Daniel Freilich Research Topics

Disease

17	Hemorrhagic Shock 02/2013 - 10/2004
12	Hemorrhage 04/2014 - 10/2004
7	Wounds and Injuries (Trauma) 04/2014 - 10/2008
6	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2014 - 11/2006
6	Hypotension (Low Blood Pressure) 04/2010 - 09/2005
4	COVID-19 10/2022 - 01/2022
4	Shock 02/2013 - 03/2002
4	Tachycardia (Tachyarrhythmias) 11/2006 - 09/2005
3	Pulmonary Hypertension 08/2012 - 03/2002
2	Chronic Pain 04/2014 - 06/2013
2	Necrosis 04/2014 - 05/2006
2	Multiple Trauma (Multiple Injuries) 02/2013 - 05/2012
2	Malaria 01/2011 - 08/2002
2	Soft Tissue Injuries (Soft Tissue Injury) 01/2006 - 09/2005
1	Anaplasmosis 03/2022
1	Babesiosis (Piroplasmosis) 03/2022
1	Ehrlichiosis 03/2022
1	Venous Thromboembolism 01/2022
1	Heart Failure 01/2022
1	Myocardial Infarction 01/2022
1	Acute Kidney Injury (Acute Renal Failure) 01/2022
1	Pain (Aches) 04/2014
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 04/2014
1	Stroke (Strokes) 02/2009
1	Hypertension (High Blood Pressure) 02/2009
1	Acute Coronary Syndrome 02/2009
1	Inflammation (Inflammations) 06/2008
1	Crush Injuries 06/2008
1	Intraoperative Complications 08/2007
1	Brain Injuries (Brain Injury) 11/2006
1	Sudden Infant Death (SID) 07/2006
1	Alkalosis 07/2006
1	Endotoxemia 03/2002

Drug/Important Bio-Agent (IBA)

20	HBOC 201 (Hemopure)IBA 08/2012 - 10/2004
15	Oxygen (Dioxygen)IBA 02/2013 - 10/2004
15	Hemoglobins (Hemoglobin)IBA 02/2013 - 10/2004
6	recombinant FVIIa (rFVIIa)FDA Link 04/2014 - 06/2008
5	Hydroxyethyl Starch Derivatives (Pentastarch)FDA Link 04/2010 - 10/2004
3	SolutionsIBA 06/2013 - 01/2009
3	Lactic Acid (Lactate)FDA LinkGeneric 02/2013 - 07/2006
3	Blood Substitutes (Artificial Blood)IBA 02/2012 - 03/2002
2	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 08/2022 - 01/2022
2	Chloroquine (Aralen)FDA LinkGeneric 08/2022 - 01/2022
2	AntibodiesIBA 03/2022 - 08/2002
2	Ringer's LactateIBA 02/2013 - 05/2012
2	Sodium NitriteIBA 05/2012 - 08/2011
2	EnzymesIBA 06/2011 - 05/2006
2	Biomarkers (Surrogate Marker)IBA 01/2011 - 02/2009
2	Nitroglycerin (Dynamite)FDA LinkGeneric 05/2010 - 04/2010
2	Hemostatics (Antihemorrhagics)IBA 10/2008 - 06/2008
1	Losartan (Cozaar)FDA LinkGeneric 10/2022
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2022
1	Angiotensin Receptor AntagonistsIBA 01/2022
1	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 08/2012
1	Lipase (Acid Lipase)FDA Link 06/2011
1	Amylases FDA Link 06/2011
1	CytokinesIBA 04/2011
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2010
1	MethemoglobinIBA 04/2010
1	TroponinIBA 02/2009
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2009
1	Glial Fibrillary Acidic ProteinIBA 01/2009
1	Blood Coagulation Factors (Coagulation Factor)IBA 10/2008
1	CationsIBA 07/2006
1	AcidsIBA 07/2006
1	AnionsIBA 07/2006
1	MB Form Creatine KinaseIBA 05/2006
1	Creatine Kinase (Creatine Phosphokinase)IBA 05/2006
1	Carrier Proteins (Binding Protein)IBA 08/2002
1	diaspirin-cross-linked hemoglobinIBA 03/2002
1	Dopamine (Intropin)FDA LinkGeneric 03/2002
1	Adrenergic Agents (Adrenergic Drugs)IBA 03/2002

Therapy/Procedure

19	Resuscitation 02/2013 - 09/2005
4	Therapeutics 01/2022 - 07/2006
2	Catheters 02/2013 - 11/2007
1	Critical Care (Surgical Intensive Care) 01/2022
1	Artificial Respiration (Mechanical Ventilation) 01/2022
1	Intravenous Infusions 05/2010
1	Blood Transfusion (Blood Transfusions) 02/2009
1	Orthopedic Procedures 02/2009
1	Anesthesia 08/2007